.cytochrome.cytochrome_list1 ul li:before {
    width: 4px;
    height: 4px;
  }
  
  .exacer-main {
  }
  
  .exacerbation {
    padding: 60px 0 93px 0;
  }
  
  .exacer-head {
    padding: 0;
  }
  
  .black-bold {
    font-weight: 900;
  }
  
  .exacer-head h1 {
    color: #656969;
    font-family: "Helvetica Neue";
    font-size: 20px;
    line-height: 25px;
    font-weight: bold;
    position: relative;
    padding-top: 10px;
    padding-top: 10px;
    margin-bottom: 55px;
    display: inline-block;
    border-top: 2px solid #656969;
    margin-left: 15px;
  }
  
  .albuterol {
  }
  
  .albuterol-in {
    max-width: 792px;
    border-radius: 8px;
    padding: 34px 30px 28px 30px;
    background: #ffffff;
    border: 1px solid #9db0ac;
    -webkit-box-shadow: 10px 10px 0px 0px rgb(216 223 222);
    -moz-box-shadow: 10px 10px 0px 0px rgba(216, 223, 222, 1);
    box-shadow: 10px 10px 0px 0px rgb(216 223 222);
    margin: 0 auto;
  }
  
  .albuterol-in p {
    font-family: "Lexia";
    font-weight: normal;
    color: #413434;
    font-size: 24px;
    line-height: 28px;
  }
  
  .mandalasec-main {
    background:rgba(235, 239, 238, 0.5)
  }
  
  .mandala-study {
    display: flex;
    padding: 96px 0 29px 0;
  }
  
  .mandala-study-cnt {
    width: 46%;
  }
  
  .mandala-study-cnt h2 {
    font-family: Lexia;
    font-size: 30px;
    line-height: 36px;
    color: #003864;
    margin-bottom: 28px;
  }
  
  .mandala-study-cnt h3 {
    font-family: "Helvetica Neue";
    font-size: 24px;
    line-height: 28px;
    color: #830051;
    font-weight: 500;
    margin-bottom: 12px;
  }
  
  .mandala-study-cnt p {
    font-family: "Helvetica Neue";
    font-size: 18px;
    line-height: 28px;
    color: #3c4242;
    max-width: 420px;
  }
  
  .mandala-study-view {
  }
  
  .mandala-study-view figure {
    margin: 0;
  }
  
  .mandala-study-view figure img {
  }
  
  .mandala-study-view {
    width: 50%;
  }
  
  .annualized-main {
    padding: 20px 0 30px 0;
  }
  
  .annualized {
    display: flex;
    justify-content: space-between;
  }
  
  .annualized-list {
    width: 48%;
  }
  
  .annualized-list-in {
    border-radius: 8px;
    padding: 30px 20px 30px 23px;
    background: #ffffff;
    border: 1px solid #9db0ac;
    -webkit-box-shadow: 10px 10px 0px 0px rgb(216 223 222);
    -moz-box-shadow: 10px 10px 0px 0px rgba(216, 223, 222, 1);
    box-shadow: 10px 10px 0px 0px rgb(216 223 222);
    min-height: 280px;
  }
  
  .endpoint {
  }
  
  .endpoint h4 {
    padding-bottom: 12px;
    font-family: "Helvetica Neue";
    font-weight: 500;
    font-size: 20px;
    line-height: 25px;
    color: #003864;
  }
  
  .annualized-list-in .endpoint ul {
    padding-left: 7px;
  }
  
  .endpoint li {
    position: relative;
    padding-left: 10px;
    margin-bottom: 10px;
  }
  
  .endpoint ul li:before {
    content: "";
    position: absolute;
    left: 0;
    top: 12px;
    background: #2F2F2F;
    width: 4px;
    height: 4px;
    border-radius: 100%;
  }
  
  .endpoint li p {
    font-family: "Helvetica Neue";
    font-weight: normal;
    font-size: 18px;
    line-height: 28px;
    color: #3c4242;
  }
  
  .inclusion-point {
    padding: 0;
  }
  
  .inclusion-point a {
    font-family: "Helvetica Neue";
    font-weight: normal;
    font-size: 16px;
    line-height: 18px;
    color: #455e89;
    text-decoration: underline;
  }
  
  .annualized-cnt p {
    font-family: "Helvetica Neue";
    font-weight: bold;
    font-size: 16px;
    line-height: 24px;
    color: #003864;
    max-width: 832px;
    padding-top: 58px;
  }
  
  .population-main {
  }
  
  .population {
  }
  
  .population-in {
    border-radius: 8px;
    padding: 30px 20px 42px 23px;
    background: #ffffff;
    border: 1px solid #9db0ac;
    -webkit-box-shadow: 10px 10px 0px 0px rgb(216 223 222);
    -moz-box-shadow: 10px 10px 0px 0px rgba(216, 223, 222, 1);
    box-shadow: 10px 10px 0px 0px rgb(216 223 222);
  }
  
  .population-head {
  }
  
  .population-head h4 {
    font-family: "Helvetica Neue";
    font-weight: 500;
    font-size: 20px;
    line-height: 25px;
    color: #003864;
    margin-bottom: 38px;
  }
  
  .population-head p {
    font-family: "Helvetica Neue";
    font-weight: normal;
    font-size: 14px;
    line-height: 16px;
    color: #3c4242;
    padding: 0 0 30px 0;
  }
  
  .population-gall {
    display: flex;
    justify-content: space-between;
  }
  
  .population-gall-list {
    width: 48%;
  }
  
  .population-gall-list figure {
    margin: 0;
  }
  
  .population-gall-list figure img {
    margin: 0;
    width: 100%;
  }
  
  .medication {
    padding: 40px 0 75px 0;
  }
  
  .medication p {
    font-family: "Helvetica Neue";
    font-weight: normal;
    font-size: 13px;
    line-height: 19px;
    color: #3c4242;
    padding: 0 0 2px 0; position: relative;
    padding-left: 6px;
  }
  .medication p span.special-icon { position: absolute;
    left: 0;} 
  .mand-box1 {
    border-bottom: 1px solid rgba(60, 66, 66, 0.5);
  }
  
  .mandalasec-box2 {
    padding: 50px 0 47px 0;
    border-bottom: 1px solid rgba(60, 66, 66, 0.5);
  }
  
  .severe-main {
    padding: 29px 0px 20px 0;
  }
  
  .severe-in {
  }
  
  .severe-head {
  }
  
  .severe-head p {
    font-family: "Helvetica Neue";
    font-size: 24px;
    line-height: 28px;
    color: #830051;
    font-weight: 500;
  }
  
  .severe-head p a {
    text-decoration: underline;
    color: #830051;
  }
  
  .reduction {
    display: flex;
    padding: 33px 0 0 0;
    justify-content: space-between;
  }
  
  .demons-rate {
    width: 70%;
  }
  
  .demons {
    padding: 5px 70px 0 0;
  }
  
  .demons-in {
  }
  
  .demons-in h3 {
    font-family: "Helvetica Neue";
    font-size: 20px;
    line-height: 25px;
    color: #003864;
    font-weight: bold;
  }
  
  h3.albu {
    max-width: 270px;
  }
  
  h3.albu-reduc {
    max-width: 271px;
  }
  
  .percentage-img {
    display: inline-block;
    width: 266px;
    padding: 44px 0 38px 0;
    position: relative;
    margin: 37px 0 42px 0;
  }
  
  .percentage-img figure {
    margin: 0;
  }
  
  .percentage-img figure img {
    margin: 0;
  }
  
  .percentage-img:before {
    content: "";
    position: absolute;
    left: 0;
    top: 0;
    background: rgba(177, 192, 189, 0.4);
    width: 100%;
    height: 5px;
  }
  
  .percentage-img:after {
    content: "";
    position: absolute;
    left: 0;
    bottom: 0;
    background: rgba(177, 192, 189, 0.4);
    width: 100%;
    height: 10px;
  }
  
  .graph-view {
  }
  
  .graph-view figure {
    margin: 0;
  }
  
  .graph-view figure img {
    margin: 0;
  }
  
  .zoomgrap-main {
    position: relative;
  }
  
  .zoomgrap-main figure {
    margin: 0;
  }
  
  .zoomgrap-main figure img {
    margin: 0;
  }
  
  .planned-treatment {
    padding: 35px 0 0 0;
  }
  
  .planned-treatment p {
    font-family: "Helvetica Neue";
    font-size: 13px;
    line-height: 19px;
    color: #3c4242;
    padding: 0 0 12px 0;
  }
  
  .mandalasec-box3 {
    padding: 80px 0 70px 0;
    border-bottom: 1px solid rgba(60, 66, 66, 0.5);
  }
  
  .annu {
    padding: 0;
  }
  
  .annu-head {
    padding: 0 0 30px 0;
  }
  
  .annu-head h2 {
    font-family: "Helvetica Neue";
    font-size: 24px;
    line-height: 28px;
    color: #830051;
    font-weight: 500;
  }
  
  .annu-graph {
    display: flex;
    justify-content: space-between;
  }
  
  .endpoint-head {
    background: #d8e0dd;
    padding: 12px 10px 11px 10px;
  }
  
  .endpoint-head p {
    text-align: center;
    font-size: 16px;
    line-height: 18px;
    color: #231f20;
    font-family: "Helvetica Neue";
    font-weight: bold;
  }
  
  .endpoint-head p a {
    text-decoration: underline;
    color: #231f20;
  }
  
  .endpoint-head p a:hover {
    color: #231f20;
  }
  
  .annu-graph-list {
    width: 48%;
  }
  
  .annu-graph-list figure {
    margin: 0;
    width: 100%;
  }
  
  .annu-data {
    padding: 4px 0 0 0;
  }
  
  .annu-data-cnt {
    padding: 0;
  }
  
  .annu-data-cnt p {
    font-family: "Helvetica Neue";
    font-size: 16px;
    line-height: 24px;
    color: #3c4242;
    padding-top: 20px;
    max-width: 790px;
  }
  
  .mandalasec-box5.mand-box5 {
    padding: 80px 0;
  }
  
  .mandalasec-box5.mand-box5 .annu-para p {
    font-size: 18px;
    line-height: 28px;
    margin-bottom: 32px;
    color: #3C4242;
    width: 88%;
    font-family: 'Helvetica Neue';
  }
  
  .mandalasec-box5.mand-box5 .annu-head {
    padding-bottom: 16px;
  }
  
  .mandalasec-box5.mand-box5 .annualized-wrapper .endpoint>p {
    font-family: "Helvetica Neue";
    font-weight: normal;
    font-size: 18px;
    line-height: 28px;
    color: #3c4242;
    margin-bottom: 10px;
  }
  
  .mandalasec-box5.mand-box5 .annualized-wrapper .endpoint>p.consecutive {
    font-weight: 500;
    color: #830051;
  }
  
  .mandalasec-box6.mand-box6 .cards-wrapper {
    display: flex;
    padding: 34px 0 40px;
  }
  
  .mandalasec-box6.mand-box6 .cards-wrapper .card {
    display: flex;
    gap: 18px; 
  } 
  .mandalasec-box6.mand-box6 .cards-wrapper .card .image-wrapper {
    width: 35%;
  }
  
  .mandalasec-box6.mand-box6 .cards-wrapper .card p {
    font-size: 18px;
    line-height: 28px;
    font-family: 'Helvetica Neue';
    color: #3C4242;
    width: 93%;
  }
  
  .mandalasec-box6.mand-box6 .cards-wrapper .card-2 p {
    width: 100%;
  }
  
  .mandalasec-box6.mand-box6 .graph-wrapper .graph-image {
    max-width: 686px;
    margin: 0 auto;
    margin-bottom: 40px;
  }
  
  .mandalasec-box6.mand-box6 .limitations-wrapper h3 {
    font-size: 16px;
    line-height: 19px;
    color: #003864;
    padding-top: 32px;
    padding-bottom: 8px;
  }
  
  .mandalasec-box6.mand-box6 .limitations-wrapper p {
    font-size: 18px;
    line-height: 28px;
    color: #3C4242;
    margin-bottom: 8px;
    font-family: 'Helvetica Neue';
  }
  
  .footnotes p {
    font-size: 12.8px;
    line-height: 19px;
    color: #3C4242;
    width: 66%;
    font-family: 'Helvetica Neue';
  }
  
  .mandalasec-box6.mand-box6 .limitations-wrapper ul {
    padding-left: 20px;
  }
  
  .mandalasec-box6.mand-box6 .limitations-wrapper ul li {
    font-size: 18px;
    line-height: 28px;
    color: #3C4242;
    margin-bottom: 8px;
    list-style-type: disc;
    list-style-position: outside;
    font-family: 'Helvetica Neue';
    list-style-type: none;
    position: relative;
  }
  
  .mandalasec-box6.mand-box6 .limitations-wrapper ul li::before {
    content: "";
    position: absolute;
    left: -17px;
    top: 12px;
    background: #003864;
    width: 4px;
    height: 4px;
    border-radius: 100%;
  }
  
  .mandalasec-box6.mand-box6 .limitations-wrapper {
    width: 81%;
  }
  
  .mandalasec-box5.mand-box5 .annualized-wrapper .endpoint span.bolded {
    font-weight: 500;
  }
  
  .mandalasec-box5.mand-box5 .annualized-wrapper .annualized-list-in .endpoint ul {
    padding-left: 0;
    width: 79%;
  }
  
  .mandalasec-box6.mand-box6 {
    padding: 0 0 80px;
    border-bottom: 1px solid rgba(60, 66, 66, 0.5);
  }
  
  .mandalasec-box6.mand-box6 h3 {
    font-size: 20px;
    line-height: 24px;
    font-family: 'Helvetica Neue';
    font-weight: 500;
    color: #003864;
  }
  
  .mandalasec-box5.mand-box5 .annualized-wrapper h3 {
    font-size: 20px;
    line-height: 24px;
    font-family: 'Helvetica Neue';
    font-weight: 500;
    color: #003864;
    margin-bottom: 32px;
  }
  
  .mandalasec-box5.mand-box5 .annualized {
    margin-bottom: 32px;
  }
  
  #therapeutic-Limitations .footnotes p {
    width: 100%;
    position: relative;
    padding-left: 10px;
  }
  
  #therapeutic-Limitations .reframing-main, #lung-function-study  .reframing-main {
    flex-direction: column;
    padding: 40px 40px 128px;
    width: 49%;
    margin: 0;
  }
  
  #therapeutic-Limitations .refram-block .content-container, #lung-function-study .refram-block .content-container {
    display: flex;
    position: relative;
  }
  
  #therapeutic-Limitations .refram-block .content-container .disclaimer-text, #lung-function-study .refram-block .content-container .disclaimer-text {
    position: absolute;
    bottom: 50px;
    left: 50%;
    transform: translate(-50%, 0);
    width: 58%;
    text-align: center;
  }
  
  #therapeutic-Limitations .refram-block .content-container .disclaimer-text p, #lung-function-study .refram-block .content-container .disclaimer-text p {
    font-size: 16px;
    line-height: 24px;
    color: #003864;
    font-weight: bold;
    font-family: 'Helvetica Neue';
  }
  
  #therapeutic-Limitations .refram-block .reframing, #lung-function-study .refram-block .reframing {
    width: 100%;
    padding: 0;
  }
  
  #therapeutic-Limitations .refram-block .reframing-view, #lung-function-study .refram-block .reframing-view {
    width: 100%;
  }
  
  #therapeutic-Limitations .refram-block .reframing p, #lung-function-study .refram-block .reframing p {
    padding-bottom: 24px;
  }
  
  #therapeutic-Limitations .reframing-view a.watch-video, #lung-function-study .reframing-view a.watch-video {
    margin-bottom: 0px;
    background: #455e89;
    border-radius: 4px;
    padding: 10px 0;
    text-align: center;
    width: 114px;
    cursor: pointer;
    color: #ffffff;
    display: inline-block;
    font-weight: normal;
    font-family: "Helvetica Neue";
    font-size: 16px;
    line-height: 19px;
    margin-top: 22px;
  }
  
  #therapeutic-Limitations .refram-block .reframing h3, #lung-function-study  .refram-block .reframing h3 {
    font-size: 20px;
    line-height: 24px;
    color: #3C4242;
    font-family: 'Helvetica Neue';
    font-weight: 400;
    padding-bottom: 8px;
  }
  
  #therapeutic-Limitations #mandala-publication .rethink-asthma-section-mandala .rethink-asthma-box {
    width: 32%;
    background: #ffffff;
    padding: 26px 26px;
  }
  
  #therapeutic-Limitations .rethink-asthma-section-mandala .rethink-asthma-box h3, #lung-function-study .rethink-asthma-section-mandala .rethink-asthma-box h3 {
    color: #003864;
    font-family: 'Helvetica Neue';
    font-size: 20px;
    line-height: 25px;
    font-weight: 500;
    min-height: 50px;
    margin-bottom: 13px;
    width: 95%;
  }
  
  #therapeutic-Limitations .mandalasec-box6.mand-box6 .footnotes p sup {
    left: 0px;
    top: 5px;
  }
  
  #therapeutic-Limitations .footnotes p sup {
    font-size: 72%;
    vertical-align: super;
    line-height: 0;
    position: absolute;
    top: 7px;
    left: 4px;
  }
  
  .exit-ramp-body p {
    margin-bottom: 13px;
    width: 99%;
    font-family: 'Helvetica Neue';
    font-weight: 400;
  }
  
  .exit-ramp-body ul {
    list-style-type: disc;
    list-style-position: outside;
    padding-left: 22px !important;
    padding-bottom: 26px !important;
  }
  
  .exit-ramp-body ul li {
    margin-bottom: 10px;
    font-family: 'Helvetica Neue';
    list-style-position: outside;
    list-style-type: none;
    position: relative;
    font-weight: 400;
    margin-bottom: 7px;
  }
  
  .exit-ramp-body ul li::before {
    content: "";
    position: absolute;
    left: -17px;
    top: 12px;
    background: #003864;
    width: 4px;
    height: 4px;
    border-radius: 100%;
  }
  
  .mandalasec-box5.mand-box5 .annualized .annualized-list-in {
    min-height: 350px;
  }
  
  p.alb-cnt-head {
    font-weight: bold; 
    max-width: 870px;
    color: #003864;
    
  }
  
  p.data-shown {
    font-size: 13px;
    line-height: 19px;
  }
  
  .annu-data-serv {
    padding: 12px 0 0 0;
  }
  
  .annu-data-serv p {
    font-family: "Helvetica Neue";
    font-size: 13px;
    line-height: 19px;
    color: #3c4242;
    padding-bottom: 5px;
  }
  
  .mandalasec-box4 {
    padding: 80px 0 56px 0;
    border-bottom: 1px solid rgba(60, 66, 66, 0.5);
  }
  
  .safty-adv-main {
    padding: 0;
  }
  
  .safty-adv {
  }
  
  .safty-adv-head {
    padding: 0;
  }
  
  .safty-adv-head h2 {
    font-family: "Helvetica Neue";
    font-size: 24px;
    line-height: 28px;
    color: #830051;
    font-weight: 500;
    padding: 0 0 32px 0;
  }
  
  .safty-adv-head h3 {
    font-family: "Helvetica Neue";
    font-size: 20px;
    line-height: 25px;
    color: #003864;
    font-weight: bold;
    padding: 0 0 22px 0;
  }
  
  .safty-adv-gall {
    padding: 0;
  }
  
  .safty-adv-gall figure {
    margin: 0;
  }
  
  .safty-adv-data {
    padding: 34px 0 2px 0;
    max-width: 830px;
  }
  
  .safty-adv-data p {
    font-family: "Helvetica Neue";
    font-size: 16px;
    line-height: 24px;
    color: #003864;
    font-weight: bold;
  }
  
  .safty-adv-note {
    padding: 10px 0 20px 0;
  }
  
  .safty-adv-note p {
    font-family: "Helvetica Neue";
    font-size: 13px;
    line-height: 19px;
    color: #3c4242;
  }
  
  .rethink-asthma-mandala {
    padding: 80px 0 120px 0;
  }
  
  .rethink-asthma-section-mandala {
    padding: 0;
  }
  
  .rethink-asthma-section-mandala .rethink-asthma-box {
    width: 47%;
    background: #ffffff;
    padding: 26px 26px;
  }
  
  span.bolded {
    font-weight: 500;
  }
  
  #therapeutic-Limitations #mandala-publication .rethink-asthma-section-mandala .rethink-asthma-box {
    width: 32%;
    background: #ffffff;
    padding: 26px 26px;
  }
  
  .rethink-asthma-box p.joun {
    font-family: "Helvetica Neue";
    font-size: 18px;
    line-height: 19px;
    color: #3c4242;
    font-style: italic;
    margin: 0 0 19px 0;
  }
  
  .rethink-asthma-box p span.year {
    font-style: normal;
  }
  
  .rethink-asthma-box p.astro-rec {
    font-family: "Helvetica Neue";
    font-size: 14px;
    line-height: 20px;
    color: #3c4242;
    max-width: 420px;
    margin: 0;
  }
  
  .rethink-asthma-box p.rethink-but {
    margin-bottom: 14px;
  }
  
  .refram-block {
    padding: 120px 0 30px 0;
  }
  
  .disclaimer-section {
    font-size: 16px;
    line-height: 24px;
    color: #003864;
    font-family: 'Helvetica Neue';
    font-weight: bold;
    text-align: center;
    padding: 40px 0 0;
  }
  
  .annu-adults { padding: 7px 0 0 0; float: right; clear: both;}
  .annu-adults p { font-family: 'Helvetica Neue'; font-size: 13px; line-height: 16px; color: #3C4242; max-width: 440px;}
  p.alb-cnt-head-mandala { padding-top: 10px; }

  @media screen and (min-width: 992px) {
  
    #therapeutic-Limitations .mandalasec-box6.mand-box6 .footnotes {
      width: 65%;
    }
  }
  
  @media screen and (max-width: 991px) {
    .exacer-main {
      margin-top: 130px;
    }
  
    .safty-adv-data {
      padding-top: 22px;
    }
  
    .disclaimer-section {
      text-align: left;
      padding: 4px 20px 0;
    }
  
    .exacer-head h1 {
      font-size: 16px;
      line-height: 18px;
      margin-left: 10px;
      margin-bottom: 40px;
    }
  
    .exacerbation {
      padding: 45px 0 70px 0;
    }
  
    .zoomgrap-but {
      position: absolute;
      right: 0;
      bottom: 0;
      margin-top: 0;
      width: 44px;
    }
  
    .exacer-main .content-container {
      padding-left: 10px;
      padding-right: 10px;
    }
  
    .mandalasec-box5.mand-box5,
    .mandalasec-box6.mand-box6 {
      padding: 40px 15px 65px;
    }
  
    .albuterol {
      padding: 0 10px 0 0;
    }
  
    .albuterol-in {
      padding: 20px 20px 24px 20px;
    }
  
    .mandala-study {
      display: block;
      padding: 50px 5px 29px 5px;
    }
  
    .mandala-study-cnt {
      width: 100%;
    }
  
    .mandala-study-view {
      width: 100%;
      padding-top: 20px;
    }
  
    .annualized {
      display: block;
    }
  
    .annualized-list {
      width: 100%;
      margin: 0 0 30px 0;
    }
  
    .mandala-study-cnt h2 {
      font-size: 24px;
      line-height: 28px;
      margin-bottom: 20px;
    }
  
    .mandala-study-cnt h3 {
      font-size: 20px;
      line-height: 25px;
    }
  
    .annualized-main {
      padding: 10px 0 20px 0;
    }
  
    .annualized-cnt p {
      padding-top: 10px;
      padding-left: 5px;
      padding-right: 5px;
    }
  
    .annualized {
      padding: 0 10px 0 0;
    }
  
    .population {
      padding: 0 10px 0 0;
    }
  
    .mandalasec-main .content-container {
      padding: 0;
    }
  
    .mand-box1 {
      padding: 0 10px 0 10px;
    }
  
    .mand-box2 {
      padding: 0 10px 0 10px;
    }
  
    .mand-box3 {
      padding: 35px 15px 30px 15px;
    }
  
    .mand-box4 {
      padding: 40px 15px 30px 15px;
    }
  
    .population-head p {
      font-size: 18px;
      line-height: 22px;
      padding: 0 0 20px 0;
    }
  
    .population-gall-list {
      width: 100%;
      margin: 0 0 20px 0;
    }
  
    .population-gall {
      display: block;
    }
  
    .population-in {
      padding: 30px 20px 20px 23px;
    }
  
    .medication {
      padding: 20px 5px 55px 5px;
    }
  
    .severe-head p {
      font-size: 20px;
      line-height: 25px;
    }
  
    .severe-main {
      padding: 38px 5px 20px 5px;
    }
  
    .demons-rate {
      width: 100%;
    }
  
    .demons {
      width: 100%;
      padding: 0;
    }
  
    .reduction {
      padding: 40px 0 0 0;
      display: block;
    }
  
    .demons-in {
      padding: 30px 0 0 0;
    }
  
    .percentage-img {
      margin: 25px 0 20px 0;
      width: 260px;
    }
  
    .percentage-img figure img {
      max-width: 204px;
    }
  
    .planned-treatment {
      padding: 20px 0 0 0;
    }
  
    .annu-graph {
      display: block;
    }
  
    .annu-graph-list {
      width: 100%;
      margin: 0 0 20px 0;
    }
    .annu-graph-list-block1 { margin-bottom: 28px;}
    .annu-data-cnt p {
      padding-top: 0;
    }
  
    .annu-data-cnt p.data-shown {
      font-size: 13px;
      line-height: 19px;
      padding-top: 20px;
    }
  
    .annu-data {
      padding: 0;
    }
  
    .annu-data-cnt {
      padding: 0;
    }
  
    .safty-adv-head h2 {
      padding: 0 0 18px 0;
    }
  
    .safty-adv-head h3 {
      padding: 0 0 20px 0;
    }
  
    .refram-block {
      padding: 70px 0 10px 0;
    }
  
    .mandala-study-cnt p {
      max-width: 100%;
      padding-right: 10px;
    }
  
    .mandala-study-view figure img {
      width: 100%;
    }
  
    .zoomgrap-main figure img {
      width: 100%;
    }
  
    .annu-graph-list figure img {
      width: 100%;
    }
  
    .safty-adv-gall figure img {
      width: 100%;
    }
  
   
  
    .endpoint-head p {
      font-size: 12px;
      line-height: 15px;
    }
  
    .annualized-list-in {
      min-height: auto;
    }
  
    .rethink-asthma-mandala {
      padding: 40px 0 50px 0;
    }
  
    #therapeutic-Limitations .references-inner, #lung-function-study .references-inner {
      margin-bottom: 60px;
    }
     #therapeutic-Limitations .reframing-main:first-child, #lung-function-study .reframing-main:first-child {
      flex-direction: column;
      padding: 48px 25px;
      width: 100%;
      margin: auto;
    }
  
    #therapeutic-Limitations .reframing-main:nth-child(2), #lung-function-study .reframing-main:nth-child(2) {
      flex-direction: column;
      padding: 0px 25px 170px;
      width: 100%;
      margin: auto;
    }
    #therapeutic-Limitations .refram-block .content-container, #lung-function-study .refram-block .content-container {
        display: flex;
        flex-direction: column;
      }

      .mandalasec-box6.mand-box6 .cards-wrapper {
        display: flex;
        padding: 34px 0 30px;
        flex-direction: column;
        gap: 16px;
        max-width: 700px;
        margin: 0 auto;

      }
    
      .mandalasec-box6.mand-box6 .cards-wrapper .card .image-wrapper {
        width: 25%;
      }
    
      .mandalasec-box6.mand-box6 .cards-wrapper .card {
        display: flex;
        gap: 8px;
        align-items: flex-start;
      }
        .annu-adults { float: none; padding: 18px 0 10px 0; }
  }
  
  @media screen and (max-width: 767px) {
    .rethink-asthma-section-mandala .rethink-asthma-box {
      width: 100%;
      margin-bottom: 20px;
      padding: 20px 20px 30px 20px;
    }
  
    .mandalasec-box6.mand-box6 .limitations-wrapper ul li::before {
      content: "";
      position: absolute;
      left: -13px;
      top: 12px;
      background: #003864;
      width: 4px;
      height: 4px;
      border-radius: 100%;
    }
  
    .mandalasec-box6.mand-box6 .limitations-wrapper ul {
      padding-left: 15px;
    }
  
    .albuterol-in p {
      font-family: "Lexia";
      font-weight: normal;
      color: #413434;
      font-size: 24px;
      line-height: 28px;
    }
  
    .rethink-asthma-block {
      display: block;
    }
  
    .rethink-asthma-section-mandala .rethink-asthma-box {
      width: 100%; box-shadow: 0 3px 10px rgb(0 0 0 / 0.2);
    }
  
    .rethink-asthma-section-mandala .rethink-asthma-box h3 {
      min-height: 50px;
      max-width: 100%;
    }
  
    .rethink-asthma-box p.joun {
      font-size: 18px;
      line-height: 24px;
      font-weight: 400;
    }
  
   
  
    #therapeutic-Limitations .refram-block .content-container .disclaimer-text, #lung-function-study .refram-block .content-container .disclaimer-text {
      position: absolute;
      bottom: 40px;
      left: 50%;
      transform: translate(-50%, 0);
      width: 71%;
      text-align: center;
    }
  
    
  
    .mandalasec-box6.mand-box6 .limitations-wrapper {
      width: 100%;
    }
  
    .mandalasec-box5.mand-box5 {
      padding: 40px 15px 65px;
    }
  
    .mandalasec-box6.mand-box6 {
      padding: 0 15px 40px;
      border-bottom: 1px solid rgba(60, 66, 66, 0.5);
    }
  
   
  
    #therapeutic-Limitations .refram-block .content-container .disclaimer-text, #lung-function-study .refram-block .content-container .disclaimer-text {
      position: absolute;
      bottom: 64px;
      left: 50%;
      transform: translate(-50%, 0);
      width: 71%;
      text-align: center;
    }
  
    .footnotes p {
      font-size: 13px;
      line-height: 19px;
      color: #3C4242;
      width: 100%;
      position: relative;
    }
  
    .footnotes p sup {
      position: absolute;
      top: 6px;
      left: -8px;
    }
  
    #therapeutic-Limitations .footnotes p sup {
      font-size: 72%;
      vertical-align: super;
      line-height: 0;
      position: absolute;
      top: 6px;
      left: 0px;
    }
  
    #therapeutic-Limitations  .mandalasec-box5.mand-box5  .footnotes p sup {
      position: absolute;
      top: 6px;
      left: 4px;
    }
  
    .mandalasec-box5.mand-box5 .annu-para p {
      font-size: 16px;
      line-height: 24px;
      margin-bottom: 32px;
      color: #3C4242;
      width: 100%;
      font-family: 'Helvetica Neue';
      padding-right: 2px;
    }
  
  
  
    .mandalasec-box5.mand-box5 .annualized-wrapper .annualized-list-in .endpoint ul {
      padding-left: 0;
      width: 100%;
    }
  
    #therapeutic-Limitations .rethink-asthma-section-mandala .rethink-asthma-box h3, #lung-function-study .rethink-asthma-section-mandala .rethink-asthma-box h3 {
      color: #003864;
      font-family: 'Helvetica Neue';
      font-size: 20px;
      line-height: 25px;
      font-weight: 500;
      min-height: 50px;
      margin-bottom: 20px;
      width: 100%;
    }
  
    .exit-ramp-body ul li {
      margin-bottom: 5px;
      font-family: 'Helvetica Neue';
      list-style-position: outside;
      list-style-type: none;
      position: relative;
      font-weight: 400;
      font-size: 16px;
    }
  
    .exit-ramp-subtitle {
      font-family: 'Helvetica Neue';
      margin-bottom: 13px;
      font-size: 16px;
      width: 90%;
    }
  
    .exit-ramp-body p {
      margin-bottom: 12px;
      width: 99%;
      font-family: 'Helvetica Neue';
      font-weight: 400;
      font-size: 16px;
    }
  
    .exit-ramp-body ul {
      padding-bottom: 4px !important;
    }
  
    .exit-ramp-body p sup {
      position: relative;
      top: 2px;
    }
  
    .mandalasec-box5 .endpoint li p {
      letter-spacing: -0.4px;
    }

    
  }
  
  @media screen and (max-width: 600px) {
    .severe-head p {
      max-width: 345px;
    }
  }
  
  .mandalasec .population-main .medication p .star {
    font-size: 100%;
    position: relative;
    top: 2px;
  }
  /*AIRSUPRA Medical  Web RethinkingAsthmaRescue.com Batura Updates starts here*/
  .controller p.controller-space { position: relative; padding-left:5px;}
.controller p.controller-space span.special-icon { position: absolute; left: 0;}

.planned-treatment p.remained-space { position: relative; padding-left:5px;}
.planned-treatment p.remained-space span.special-icon { position: absolute; left: 0;}


  @media screen and (min-width: 991px) {
     .rethink-asthma-rescue-mild .rethink-asthma-box { width: 23.5%; padding: 25px 20px;}
     .rethink-asthma-rescue-mild .clinic-rescue .rethink-asthma-box h3 { max-width: 210px; min-height: 93px;}
     .rethink-asthma-rescue-mild .rethink-asthma-box p { margin-bottom: 0;}   
     body .popup10.modal.cmp-modal__modalbox { display: none;}

     .mandalasec-box6.mand-box6 .cards-wrapper .card p
     {
        width: 95%;
     }
     .mandalasec-box6.mand-box6 .cards-wrapper .card-2 p 
     { 
        width: 90%;
     }
     
  }
  @media screen and (max-width: 991px) {
    .rethink-asthma-rescue-mild .clinic-rescue .rethink-asthma-box { padding: 20px 20px 30px 20px;}
    
     .exacer-main {margin-top: 0px;}
     .population-gall-list figure.demographics-chart   {text-align: center;}
 
     .mandalasec-box5.mand-box5 .annualized .annualized-list-in { min-height: auto;}
     
    .safty-adv-gall figure { text-align: center;}
 

     body .modal.cmp-modal__modalbox.popup9 .modal-box
    {
        padding: 70px 20px;
    }
    .exit-ramp-title
    {
        font-size: 19px;
    }
    .mandalasec-box6.mand-box6 .cards-wrapper .card p
    {
        max-width: 900px;
    }
    .mandala-study-view figure.mandala-trials-graphic
    {
        text-align: center;
    }
    .mandala-study-view figure.mandala-trials-graphic img
    {
        width: 500px;
       
    }
    .mandalasec-box6.mand-box6 .graph-wrapper .graph-image-mob
    {
        max-width: 686px;
        margin: 0 auto;
        margin-bottom: 30px;
    }
    .graph-image-mob .zoomgrap-but { bottom: 15px; }
    
    #therapeutic-Limitations #mandala-publication .rethink-asthma-section-mandala .rethink-asthma-box, #lung-function-study .rethink-asthma-section-mandala .rethink-asthma-box {
        width: 100%;
        background: #ffffff;
        padding: 26px 26px;
        box-shadow: 0 3px 10px rgb(0 0 0 / 0.2);
      }
      #therapeutic-Limitations #mandala-publication .rethink-asthma-section-mandala .rethink-asthma-box 
      {
        width: 100%;
      }
     /*clinical popup10 starts here*/
  body .popup10 {
    display: block;
  }

  body .popup10.modal.cmp-modal__modalbox {
    background: #000000;
  }

  body .popup10.modal.cmp-modal__modalbox .modal-box {
    padding: 15px;
    max-width: 84%;
    top: 20px;
    border-radius: 0;
  }

  body .popup10.cmp-modal--defaultStyle .modal-box__content {
    overflow-y: auto;
  }

  body .popup10.modal.cmp-modal__modalbox .modal__close svg {
    background: transparent;
    color: #fff;
  }

  body .popup10.modal.cmp-modal__modalbox .modal__close {
    max-width: 100%;
    top: 45px;
    padding-right:7px;
  }
    /*clinical popup10 ends here*/	
  }
  @media screen and (max-width: 767px) {
    .mandalasec-box6.mand-box6 .cards-wrapper .card .image-wrapper
    {
        width: 120px;
        margin-right: 5px;
    }
  }
  @media screen and (max-width: 667px) {
    .rethink-asthma-rescue-mild .clinic-rescue .rethink-asthma-box h3 { max-width: 270px; }
    .rethink-asthma-rescue-mild .clinic-rescue .rethink-asthma-box.first-box h3 { max-width: 190px; }
    .rethink-asthma-rescue-mild .clinic-rescue .rethink-asthma-box.fourth-box h3 { max-width: 190px; }
    
     
    
    #therapeutic-Limitations .reframing-main:nth-child(2), #lung-function-study .reframing-main:nth-child(2) {
        
        padding: 0px 25px 200px;
        
      }
      #therapeutic-Limitations .refram-block .content-container .disclaimer-text, #lung-function-study .refram-block .content-container .disclaimer-text
      {
        bottom: 64px;
      }
      .mandalasec-box6.mand-box6 .cards-wrapper .card .image-wrapper
    {
        width: 170px;
        margin-right: 5px;
    }
    .mandala-study-view figure.mandala-trials-graphic img
    {
        width: 100%; 
    }
     
  }
  /*AIRSUPRA Medical  Web RethinkingAsthmaRescue.com Batura Updates starts here*/